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. 2019 Jul 18;10:1651. doi: 10.3389/fimmu.2019.01651

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Copyright © 2019 Reyes-Sandoval and Ludert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular model of dengue virus NS1 showing regions involved in molecular mimicry with LYRIC in endothelial cells (A), with the protein disulfide isomerase in platelets (B) and plasminogen (C). Those two last epitopes overlap in one position (311). An immunodominant epitope presumably involved in protection (28) is also shown (D). Interestingly, this last epitope does not overlap with any of the epitopes related to molecular mimicry. Monomers are shown in gray and white and wing and ladders domain are indicated.