Fig. 4.

Biomarkers from the GLMM model associated with oocytes producing euploid embryos versus mature oocytes with other outcomes. To evaluate CC biomarker mRNA level association with oocytes capable of producing euploid embryos, a model was fit with 78 CC samples from 11 patients and included the biomarkers: CYP11A1, CYP19A1, HSD3B, IGFBP5, PAPPA, PGR, PGRMC1, ING1, LHCGR, and STARD1. Higher HSD3B mRNA level significantly decreased the odds of an oocyte resulting in a euploid embryo (OR = 0.408, 95% CI 0.175 to 0.953). Higher ING1 mRNA levels marginally decreased the odds of an oocyte resulting in a euploid embryo (OR = 0.552, 95% CI 0.297 to 1.027). Groups represent CC mRNA from oocytes with the following descriptions: abnormal = mature oocytes resulting in aneuploid blastocysts, oocytes producing embryos that did not reach the blastocyst stage, and mature oocytes that failed to fertilize; euploid = mature oocytes that resulted in euploid embryos regardless of whether they were transferred or remained vitrified. Data are presented as stated in Fig. 3 legend