Table 4.

All DEG regulated unigenes involved in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for sea cucumbers

KEGG pathway	Sub-pathway (Up unigene number)	Sub-pathway (Down unigene number)
Amino acid metabolism	beta-Alanine metabolism (14) Biosynthesis of amino acids (29) Lysine degradation (17) Valine, leucine, and isoleucine degradation (23)	Glycine, serine, and threonine metabolism (10) Phenylalanine metabolism (5) Tyrosine metabolism (5) Glutathione metabolism (7)
Carbohydrate metabolism	Butanoate metabolism (11) Carbon metabolism (55) Citrate cycle (TCA cycle) (15) Glycolysis/gluconeogenesis (19) Glyoxylate and dicarboxylate metabolism(14) Pentose phosphate pathway (10) Propanoate metabolism (20) Pyruvate metabolism (18) Galactose metabolism (9)	Other glycan degradation (5) Glycosphingolipid biosynthesis (2) Glycosaminoglycan degradation (3)
Lipid metabolism	Fatty acid degradation (33) Fatty acid elongation (12) Fatty acid metabolism (36)	Glycerolipid metabolism (7) Linoleic acid metabolism (4) Glycerophospholipid metabolism (7) Sphingolipid metabolism (5)
Genetic information processing	Proteasome (18)	Ribosome (78) Protein processing in endoplasmic reticulum (16) Ubiquitin mediated proteolysis (12)
Metabolism of cofactors and vitamins	Retinol metabolism (10)	Retinol metabolism (8) Ubiquinone and other terpenoid -quinone biosynthesis (3)
Transport and catabolism	Peroxisome (36)	Lysosome (20) Regulation of autophagy (3)
Environmental information processing	ECM-receptor interaction (19)	mTOR signaling pathway (5) ABC transporters (3)