Fig. 5.

Positive correlation of activated OMI/HTRA2 with ChAT protein expression and activity. ChAT protein expression and activity were quantified in AD subjects’ (n = 6) and non-demented controls’ (n = 6) postmortem brain medial frontal gyrus (MFG), superior temporalis gyrus (STG), and superior parietal gyrus (SPG) regions, within the soluble (s), ionic (i), and membrane-bound (m) protein extracts, and then correlated to the activated OMI/HTRA2 levels in the same regions. a Graph showing the positive correlation of OMI/HTRA2 level and total ChAT protein level in the MFG brain region. b–d Graphs showing the positive correlation of OMI/HTRA2 level with the total ChAT (b), m-ChAT (c), and s-ChAT (d) enzymatic activity in the MFG brain region. ChAT = choline acetyltransferase