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. 2019 Jul 18;7:163. doi: 10.3389/fbioe.2019.00163

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Copyright © 2019 Bandyopadhyay, Azharuddin, Dasgupta, Ganguli, SenRoy, Patra and Deb.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The observed percentage of platelet aggregation over time in response to administration of 1.32 μM of ADP together with model based estimates of the mean percentages, and point wise first and estimated second derivatives of the mean curve. The first derivative measures the velocity of aggregation while the second derivative measures the corresponding acceleration. A horizontal line indicating zero velocity and acceleration is also plotted for reference. The gray shaded region is the 95% confidence interval.