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. 2019 May 15;170(2):404–414. doi: 10.1093/toxsci/kfz114

Figure 8.

Figure 8.

Enhanced interleukin-33 (IL-33) expression by aryl hydrocarbon receptor (AhR) ligands under inflammatory condition. A, THP-1 macrophages were treated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) (10 nM), 6-Formylindolo(3, 2-b)carbazole (FICZ) (100 nM), or kynurenine (KYN) (50 μM) for 6 h in the presence or absence of LPS (10 ng/ml). IL-33 variant 5 expression was assessed by real-time PCR. The values represent the mean ± SE (n = 4). Data were analyzed using a one-way analysis of variance (ANOVA), followed by Dunnett's test or a t test. **p < .01 versus the No Add, control group. ##p < .01 versus the No Add group. B, Human macrophages derived from blood monocytes were treated with TCDD (1 nM), FICZ (100 nM), or KYN (50 μM) in the presence or absence of CL075 (5 μg/ml) for 24 h. Real-time PCR was performed to measure IL-33 variant 5 mRNA. The values represent the mean ± SE (n = 3). Data were analyzed using a one-way ANOVA, followed by Dunnett's test or a t test. *p < .05, **p < .01 versus the No Add, control group. ##p < .01 versus the No Add group.