Table 7.
The effect of MSA weighting and averaging on tree accuracy for empirical data
| Base MSA (MAFFT) | GUIDANCE2 weighting | SuperMSA | ||||
|---|---|---|---|---|---|---|
| Average normalized RF distance | Average normalized RF distance |
 -value |
Average normalized RF distance |
 -value |
GUIDANCE2 SPC score for base MSA | |
| Bacteria | 0.571 (0.34) | 0.565 (0.338) | 0.1154 | 0.56 (0.333) | 0.023 | 0.89 (0.09) |
| Fungi | 0.158 (0.241) | 0.141 (0.23) | 0.0116 | 0.128 (0.218) | 0.000146 | 0.89 (0.1) |
| Eukaryota | 0.087 (0.185) | 0.087 (0.181) | 0.5125 | 0.087 (0.172) | 0.504 | 0.89 (0.12) |
Notes: All 
-values were computed using a one-sided Wilcoxon test. In parenthesis are standard deviations. Statistically significant values are in bold.