Table 1.
Antibodies against | Mechanism | Confirmed with: | ||
---|---|---|---|---|
Mouse Abs | Human Abs | |||
HA (head) | Neutralizing (strain specific) | Block virus attachment to host cell | ✓a | ✓ |
Broadly neutralizing | ✓ S139/1b (43)c | ✓ CH65, C05, F045-092, F026-427, D1-8 (44–47) |
||
Non-neutralizing | ADCC | |||
ADCP | ||||
CDCC | (92) | |||
Inhibit NA activity | ✓ (30, 32) | |||
HA (stem) | Broadly neutralizing | Block fusion | ✓ C179 (48) | ✓ CR6261, CR8020, FI6, F10 (48–52) |
Non-neutralizing | ADCC | FI6 (84) | ||
ADCP | ✓ (91) | ✓ (91) | ||
CDCC | ✓ (92) | |||
Inhibit NA activity | ✓ (32) | ✓ (31) | ||
NA | Neutralizing | Not described | ✓ (66) | |
Non-neutralizing | NI-activity, interfere with viral release | ✓ (76) | ✓ (66) | |
ADCC | ✓ (87) | |||
M2 | Non-neutralizing | ADCC | ✓ 1–10 (99) | |
ADCP | ✓ (98) | |||
CDCC | ✓ (101) | |||
NP | Non-neutralizing | ADCC | ✓ (87) | |
CDCC | ✓ Low activity (123) |
✓ indicates that the mechanism of action has been confirmed.
mAb name.
Reference in parenthesis.