Method summary	Fluorescence reporting (indirect)
Requirements	Fluorescence spectrophotometer and quartz cuvette or fluorescence plate reader for high throughput analysis and suitable fluorescent reporter dyes.
Results	Indirect evidence of DNA binding when combined with specific reporter dyes. Binding constant can be obtained for compounds lacking a chromophore.
Advantages	High-throughput analysis possible when combined with 96 well plates.
Limitation	Indirect method with a reliance on signal from a fluorogenic reporter. Quenching of the reporter by metallodrug must be examined prior to analysis.
Complementary and advanced techniques	NMR, mass spectrometry and viscosity (Sections 2.2, 2.3, and 2.4) and optical techniques including thermal melting and circular dichroism (Sections 3.1.1 and 3.1.2). Advanced techniques include surface plasmon resonance (SPR) and molecular dynamics.