Method summary	NMR analysis (direct)
Requirements	Good solubility. Labelled compounds (e.g.15N) best although natural abundance can be used in favourable circumstances.
Results	Conformation of metallodrug–DNA solution interactions.
Advantages	Modification of electronic properties of complex upon binding to oligonucleotide; kinetics of bond formation upon initial pre-association.
Limitations	Need NMR active nuclei and mainly diamagnetic compounds.
Complementary and advanced techniques	X-ray and MS (direct) (Sections 2.1 and 2.3).
	HSQC NMR can be combined with 3-D NOESY-HSQC or TOCSY-HSQC.
	Saturation transfer difference (STD) NMR to study transient complex-biomolecule interactions.