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. 2019 Jul 18;10:1695. doi: 10.3389/fimmu.2019.01695

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Copyright © 2019 Marín-Sánchez, Álvarez-Sierra, González, Lucas-Martin, Sellés-Sánchez, Rudilla, Enrich, Colobran and Pujol-Borrell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of GD-associated SNPs (rs179247 and rs12101255) on the expression of TSHR alternatively spliced isoforms in human thyroid and thymus samples. The relative level of flTSHR, ST4, and ST5 expression was measured by qPCR and normalized to the level of GAPDH expression. The ratio of each short ST4 and ST5 transcript to the flTSHR was calculated for each individual and the data were grouped by SNP genotype. (A–F) The relative ST4 and ST5 expression in the thyroid is presented. (G–L) Relative level of ST4 and ST5 expression in the thymus is presented. A non-GD-associated SNP (rs2288495) was also included as a control. Each point represents the mean value of triplicate results from one sample. The mean ± SEM of each group is shown. A Kruskal-Wallis with Dunn's multiple comparison test was used.