Table 3.

Regulation of Significant mRNAs in Monocytes by Top 10 miRNAs in Exosomes

miRNA	Predicted No. of Regulated Genes	Genes Predicted to Be Regulated
miR-6126	1	DHCR7
miR-6780b-5p	3	KCNE1, LSS, MSC
miR-3197	1	NUPR1
miR-22-3p	4	CCL4L1, INSIG1, KLF6, RGS2
miR-122-5p	3	CD83, KCNJ2, SLC7A11
miR-1273h-5p	5	CXCL10, RHOB, SLC12A8, SLCO4C1, TNFRSF9
miR-149-3p	12	ACSS2, BTG2, CCL3, CSF1, CXCL10, IFI44L, IFIT3, IL32, MVK, RHOB, SLCO4C1, TNF
miR-192-5p	6	ATF3, CSF1, FABP3, FLT1, IFI44L, IL21R
miR-148a-3p	4	CSF1, FLT1, KLF6, LIPG
miR-6875-5p	3	CHAC1, CXCL10, SH2D3C

Genes in bold function in an immune response.

Abbreviations: DHCR7, 7-dehydrocholesterol reductase; KCNE1, potassium voltage-gated channel subfamily E regulatory subunit 1; LSS, lanosterol synthase; MSC, musculin; NUPR1, nuclear protein 1; CCL4L1, C-C motif chemokine ligand 4 like 1; INSIG1, insulin-induced gene 1; KLF6, Kruppel-like factor 6; RGS2, regulator of G protein signaling 2; CD83, cluster of differentiation 83; KCNJ2, potassium voltage-gated channel subfamily J member 2; SLC7A11, solute carrier family 7 member 11; CXCL10, C-X-C motif chemokine ligand 10; RHOB, Ras homolog family member B; SLC12A8, solute carrier family 12 member 8; SLCO4C1, solute carrier organic anion transporter family member 4C1; TNFRSF9, tumor necrosis factor (TNF) receptor superfamily member 9; ACSS2, acyl-CoA synthetase short-chain family member 2; BTG2, BTG antiproliferative factor 2; CCL3, C-C motif chemokine ligand 3; CSF1, colony stimulating factor 1; IFI44L, interferon-induced protein 44 like; IFIT3, interferon-induced protein with tetratricopeptide repeats 3; IL32, interleukin (IL) 32; MVK, mevalonate kinase; ATF3, activating transcription factor 3; FABP3, fatty acid-binding protein 3; FLT1, fms-related tyrosine kinase 1; IL21R, IL-21 receptor; LIPG, lipase G, endothelial type; CHAC1, ChaC glutathione-specific gamma-glutamylcyclotransferase 1; SH2D3C, SH2 domain containing 3C.