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. 2019 Jul 22;7:e7380. doi: 10.7717/peerj.7380

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©2019 Liu and Ye

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) Vocalno plot indicating the significantly differentially expressed miRNAs in LSCC (p < 0.01 and fold change of >2). (B) GO and KEGG enrichment analysis of the target genes of altered miRNAs. The association between miRNA-mRNA pairs, biological processes, and signaling pathways was determined by CluePedia. Pink squares represent differentially expressed miRNAs, and yellow circles represent target genes. Blue circles and triangles represent processes and pathways, respectively. (C) Venn diagram showing the intersection of the predicted mRNAs and all differentially expressed mRNAs. (D) The global view of the ceRNA network in LSCC. Diamonds and squares represent lncRNAs and miRNAs, respectively. Ovals represent mRNAs. Red nodes represent upregulation and blue nodes represent downregulation.