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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Lung Cancer. 2018 Nov 19;127:25–33. doi: 10.1016/j.lungcan.2018.11.020

Fig. 3.

Fig. 3.

Representative images of low and high PD-L1 expression as detected on PECs by CellSearch and IHC staining of pleural effusions. (A) Patient 022: CellSearch detected 11,404 PECs/mL, 1.4% of which expressed PD-L1. IHC staining determined the PD-L1 expression to be 0%. (B) Patient 017: CellSearch detected 1,762 PECs/mL, 94% of which were PD-L1 positive. >95% of cells stained PD-L1 positive by IHC. Concordance between CellSearch and IHC staining for PD-L1 expression was 76%. (C) PD-L1 expression in malignant effusions for the 69 patients confirmed malignant by pathology. The median value in the malignant group was 6.9%. Dotted horizontal line indicates that 15 out of 69 patients (22%) had 50% or more PD-L1+ PECs. Solid horizontal line indicates median value in panel.