Table 3.

The models or approaches for the prediction of half-life.

Number	Model name or approaches of half-life	Description of the models	Reference
1	Model of peptide half-life (HLP)	For HLP in intestine-like environment based on 10mer (HL10) and 16mer (HL16) peptides dataset	(Sharma et al., 2014)
2	An approach to predict elimination half-life in human	Seven machine learning methods and molecular descriptors	(Lu et al., 2016)
3	The prediction model of 20 cephalosporins	By the integration of constitutional, topological, and quantum-chemical descriptors	(Turner et al., 2010)
4	Two half-life prediction models in humans	Based on molecular fragments and an automated iterative fragment selection method	(Arnot et al., 2014)
5	PreHL model	The C-partial least square (C-PLS) algorithm	(Yang et al., 2014)