Table 5.

The approaches for the prediction of drug combination.

Number	Approach name	Description	Reference
1	High-throughput screening method	In vitro approaches	(Borisy et al., 2003; Lehár et al., 2009)
2	Multiplex screening for interacting compounds (MuSIC)	In vitro approaches	(Tan et al., 2012)
3	Several computational approaches	By integrating network analysis and chemical biology data	(Chou, 2010; Zhao et al., 2011; Tang et al., 2013)
4	Simple feature-enrich method	By simple feature-enrich method to predict drug combinations	(Zhao et al., 2011)
5	Probability ensemble approach (PEA model)	By the integration of the molecular chemical space, the pharmacological space, the gene annotations, and the biological networks	(Li et al., 2015b)