Table 5.
Comparison | Gene Symbol | Gene Name | Role in Cancer | Function |
---|---|---|---|---|
Minke:humpback | CD274 | CD274 molecule | TSG | Plays a critical role in induction and maintenance of immune tolerance to selfa |
ETNK1 | Ethanolamine kinase 1 | TSG | Suppresses escaping of programmed cell deathb | |
IL21R | Interleukin 21 receptor | Fusion | The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3.2 | |
MYOD1 | Myogenic differentiation 1 | Fusion | Regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiationa | |
PHF6 | PHD finger protein 6 | TSG | Encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolusa | |
Orca:dolphin | BTG1 | B-cell translocation gene 1; antiproliferative | TSG; fusion | Member of an antiproliferative gene family that regulates cell growth and differentiationa |
CD274 | CD274 molecule | TSG; fusion | Plays a critical role in induction and maintenance of immune tolerance to selfa | |
FANCD2 | Fanconi anemia; complementation group D2 | TSG | Suppresses genome instability and mutations; promotes escaping programmed cell death; suppresses proliferative signaling; suppresses invasion and metastasisb | |
FAS | Fas cell surface death receptor | TSG | Promotes cell replicative immortality; promotes proliferative signaling; promotes invasion and metastasis; suppresses escaping programmed cell deathb | |
FGFR4 | Fibroblast growth factor receptor 4 | Oncogene | Promotes proliferative signaling; promotes invasion and metastasisb | |
GPC3 | Glypican 3 | Oncogene; TSG | Promotes invasion and metastasis; promotes suppression of growthb | |
HOXD11 | Homeobox D11 | Oncogene; fusion | The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organismsa | |
HOXD13 | Homeobox D13 | Oncogene; fusion | ||
LASP1 | LIM and SH3 protein 1 | Fusion | The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancera | |
MLF1 | Myeloid leukemia factor 1 | TSG; fusion | This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemiaa | |
MYB | v-myb myeloblastosis viral oncogene homolog | Oncogene; fusion | This gene may be aberrantly expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogenea | |
MYD88 | Myeloid differentiation primary response gene (88) | Oncogene | Promotes escaping programmed cell death; promotes proliferative signaling; promotes invasion and metastasis; promotes tumor promoting inflammationb | |
NR4A3 | Nuclear receptor subfamily 4; group A; member 3 (NOR1) | Oncogene; fusion | Encodes a member of the steroid–thyroid hormone–retinoid receptor superfamily that may act as a transcriptional activatora | |
PALB2 | Partner and localizer of BRCA2 | TSG | This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2a | |
PML | Promyelocytic leukemia | TSG; fusion | Expression is cell-cycle related and it regulates the p53 response to oncogenic signalsa | |
RAD21 | RAD21 homolog (Schizosaccharomyces pombe) | Oncogene; TSG | Promotes invasion and metastasis; suppresses genome instability and mutations; suppresses escaping programmed cell deathb | |
STIL | SCL/TAL1 interrupting locus | Oncogene; fusion | Encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cellsa | |
TAL1 | T-cell acute lymphocytic leukemia 1 (SCL) | Oncogene; fusion | Implicated in the genesis of hemopoietic malignancies and may play an important role in hemopoietic differentiationa | |
TNFRSF14 | Tumor necrosis factor receptor superfamily; member 14 (herpesvirus entry mediator) | TSG | The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune responsea | |
TNFRSF17 | Tumor necrosis factor receptor superfamily; member 17 | Oncogene; fusion | This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferationa |
Note.—TSG, tumor suppressor gene.
Source: RefSeq.
Source: Cancer Hallmark from CGC.