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. 2019 Apr 19;36(8):1686–1700. doi: 10.1093/molbev/msz091

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© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 5. — Conservation in amino acid sequence of the ZnF repeats located in positions 3–6 (ZnF3–ZnF6) along the ZnF array in PRDM9 heterozygous combinations found in the study. (A) Bubble chart representing population frequency (size of the bubble) and the percentage of amino acid (Aa) sequence conservation of the highly variable positions (−1, +3, and +6) of the initial repeats along the array (from ZnF3 to ZnF6) (purple intensity). Data are shown for each heterozygous combination found in Standard and Rb mice in the Barcelona Rb system and the Madeira archipelago (see supplementary table 7, Supplementary Material online, for further details). (B, C) Examples of PRDM9 alleles in heterozygous combination and the predicted distribution of recombination hotspots. Yellow starts represent the location of recombination hotspots across homologous chromosomes (red and blue lines). (B) The ZnF repeats located in positions 3–6 (ZnF3–ZnF6) in the 10A/12E combination present 100% of Aa sequence conservation. This can result in symmetric distribution of recombination hotspot in homologous chromosomes. (C) The ZnF repeats located in positions 3–6 (ZnF3–ZnF6) in the 10B/11B combination present 33.3% of Aa sequence conservation. This can result in asymmetric distribution of recombination hotspot in homologous chromosomes.