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FDA-approved platinum drugs and their DNA intrastrand GpG cross-link adducts. Chloride and dicarboxylate moieties of platinum-based drugs are replaced by water molecules to form reactive aquated platinum species, which preferentially attack the two N7 atoms of adjacent purines. Cisplatin and carboplatin produce the identical (NH3)2Pt-GG adducts, whereas oxaliplatin produces [1,2-cyclohexanediamine]-Pt-GG adducts.
