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. 2019 Jul 25;14(7):e0219766. doi: 10.1371/journal.pone.0219766

Table 2. Gender-stratified frequencies of malignancies and age-standardized incidence rates weighted for China (ASIRC) and for the world (ASIRW), 2008 to 2011.

Malignancy Site/Type (ICD-O-3 Code) Males, per 100,000 Females, per 100,000
N ASIRCa (CI) ASIRWb (CI) N ASIRCa (CI) ASIRWb (CI)
All Cancers 2,808 776.4 (742.1–810.6) 881.7 (839.6–923.7) 1,011 486.5 (436.4–536.6) 508.9 (454.0–563.7)
    All (Excluding Ill-defined/Unspecified) 2,524 691.8 (659.7–724.0) 782.7 (743.3–822.0) 898 427.4 (380.5–474.2) 446.0 (394.7–497.3)
    Ill-defined/Unspecified 284 84.6 (72.8–96.3) 99.0 (84.2–113.9) 113 59.2 (41.5–76.8) 62.8 (43.5–82.1)
AIDS-Defining Cancers (all lymphomasc)
    Kaposi sarcoma (9140) 132 23.9 (18.9–28.8) 23.9 (18.5–29.2) 39 14.2 (9.0–19.4) 13.9 (8.5–19.2)
    Lymphomac (959, 965) 299 63.1 (54.6–71.7) 65.8 (56.3–75.4) 117 48.0 (32.7–63.2) 48.8 (32.3–65.2)
    Cervical (C53) - - - 128 47.6 (38.3–57.0) 48.0 (38.3–57.8)
Non-AIDS-Defining Cancers (no lymphomasc)
    Oral cavity (C00–C09) 13 5.3 (2.1–8.4) 6.6 (2.3–10.8) 4 1.9 (0.0–3.9) 2.0 (0.0–4.2)
    Nasopharynx (C11) 38 11.0 (7.1–15.0) 12.0 (7.6–16.3) 9 3.8 (1.1–6.6) 4.3 (1.1–7.4)
    Other head and neck (C12–C14, C30–C32) 47 13.8 (9.1–18.6) 15.9 (10.0–21.7) 17 7.6 (3.3–11.8) 8.0 (3.4–12.7)
    Esophagus (C15) 78 25.3 (19.0–31.7) 29.0 (21.4–36.7) 19 14.8 (1.8–27.9) 16.1 (1.7–30.4)
    Stomach (C16) 137 44.1 (35.6–52.6) 52.6 (41.6–63.5) 60 47.8 (24.2–71.4) 51.4 (25.5–77.3)
    Colon and rectum (C18–20) 121 34.4 (27.3–41.5) 39.2 (30.5–47.9) 32 22.0 (11.0–33.0) 23.1 (11.3–34.8)
    Anus (C21) 2 0.2 (0.0–0.5) 0.2 (0.0–0.4) 0 - -
    Liver (C22) 539 145.7 (131.0–160.3) 160.8 (143.6–178.0) 84 39.2 (27.4–51.0) 41.4 (28.7–54.2)
    Other digestive system (C23, C24, C26) 6 1.8 (0.2–3.4) 2.6 (0.0–5.3) 1 0.7 (0.0–2.2) 0.9 (0.0–2.6)
    Pancreas (C25) 41 12.0 (7.8–16.3) 14.2 (8.8–19.5) 2 5.0 (0.0–14.3) 6.4 (0.0–18.6)
    Lung (C34) 713 226.0 (206.7–245.4) 266.3 (241.8–290.8) 140 66.8 (52.5–81.1) 71.3 (55.7–86.9)
    Mediastinum and pleura (C38) 4 0.7 (0.0–1.5) 0.7 (0.0–1.5) 2 0.5 (0.0–1.3) 0.5 (0.0–1.1)
    Bone (C40) 11 4.2 (1.3–7.0) 5.3 (1.4–9.2) 2 0.9 (0.0–2.1) 1.0 (0.0–2.5)
    Skin (C44) 17 4.6 (2.1–7.2) 5.0 (2.2–7.9) 9 3.2 (1.0–5.3) 3.2 (1.0–5.5)
    Soft tissue (C47–C49) 5 1.1 (0.0–2.3) 1.1 (0.0–2.5) 7 2.1 (0.5–3.7) 2.1 (0.5–3.7)
    Breast (C50) 2 0.3 (0.0–0.8) 0.3 (0.0–0.8) 31 13.6 (7.0–20.2) 14.1 (7.1–21.2)
    Vagina and vulva (C51, C52) - - - 2 0.7 (0.0–1.7) 0.7 (0.0–1.8)
    Corpus uteri (C54) - - - 48 24.9 (10.8–39.0) 26.2 (10.9–41.6)
    Ovary and other female genital tissue (C55–C58) - - - 5 1.7 (0.2–3.1) 1.7 (0.1–3.4)
    Penis (C60) 6 2.1 (0.2–3.9) 2.4 (0.3–4.5) - - -
    Prostate (C61) 9 4.3 (1.3–7.3) 6.1 (1.7–10.5) - - -
    Other male genital (C62, C63) 5 1.1 (0.0–2.5) 1.2 (0.0–2.6) - - -
    Kidney (C64) 10 2.5 (0.5–4.5) 2.9 (0.4–5.3) 2 0.6 (0.0–1.5) 0.6 (0.0–1.5)
    Other urinary system (C65–C68) 3 0.8 (0.0–1.8) 0.9 (0.0–2.0) 0 - -
    Bladder (C67) 9 3.8 (1.1–6.6) 5.6 (1.2–9.9) 1 0.7 (0.0–2.2) 0.9 (0.0–2.6)
    Eye (C69) 4 1.1 (0.0–2.4) 1.1 (0.0–2.6) 3 1.1 (0.0–2.5) 1.2 (0.0–2.6)
    Brain and CNS (C70, C71) 216 45.5 (38.2–52.8) 47.4 (39.2–55.6) 105 43.0 (28.5–57.6) 43.0 (27.3–58.7)
    Thyroid (C73) 2 0.4 (0.0–1.0) 0.4 (0.0–1.0) 0 - -
    Multiple myeloma (C90) 4 2.0 (0.0–4.0) 2.3 (0.0–4.6) 1 0.4 (0.0–1.3) 0.5 (0.0–1.6)
    Melanoma (872) 1 0.3 (0.0–0.9) 0.4 (0.0–1.1) 0 - -
    Leukemia (981) 50 10.3 (6.8–13.8) 10.7 (6.7–14.6) 28 14.4 (6.1–22.6) 14.6 (5.9–23.4)

ICD-O-3: International Classification of Disease for Oncology [32], 3rd Edition, ASIRC: age-standardized incidence rate for China, ASIRW: age-standardized incidence rate for the world, CI: 95% confidence interval, CNS: central nervous system

aASIRC is per 100,000, weighted by Chinese population in 2010 according to national census data [33], and CI calculated based on an assumed Poisson distribution

bASIRW is per 100,000, weighted by the World Health Organization’s world standard population data for 2002 to 2025 [34], and CI calculated based on an assumed Poisson distribution

cBecause approximately half of lymphoma records did not specify Hodgkin or Non-Hodgkin lymphoma, combined observed and expected lymphoma figures were calculated