Fig 4. Log₂ fold-changes of gene expression between men and women in early RA, established RA and normal condition.

Only genes are shown which are significantly differentially expressed in men and women. (A) The sex-ratio of gene expression in early RA and normal condition. The size and shape shows the significance in differences of men and women: the large circles are genes significantly differentially expressed between the sexes in early RA and normal condition, these genes are also labelled. Small squares mean a significant difference between men and woman only in early RA, small diamonds mean a significant difference only between healthy men and woman. The color represents the significance of the difference in expression between normal and early RA. (B) The sex-ratio of gene expression in established RA and early RA. There are no gene significantly differentially expressed in men and women in established RA and early RA and differentially expressed between established RA and early RA. Genes are named if one of the gene expression sex-ratios is significant: squares mean a significant difference between men and woman only in established RA, small diamonds mean a significant difference only between men and woman in early RA.