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. 2019 Jul 30;25(3):442–460. doi: 10.5056/jnm19014

Figure 10.

Figure 10

Chronic stress enhances extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in vagal afferents. (A) Phospho-ERK1/2 (p-ERK1/2) labeling in nodose neurons 10 minutes after intra-antral infusion of warm or cold (0°C) saline in rats previously subjected to a 10-day sham stress or water avoidance stress (WAS). Arrows indicate p-ERK1/2-immunoreactive (IR) neurons. Scale bar = 100 μm. (B) Proportions of p-ERK1/2-IR neurons in nodose ganglia after antral infusion of warm or cold saline in sham stress and stressed rats. *P < 0.05, **P < 0.01 (Student’s t test).