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. 2019 Jul 30;25(3):442–460. doi: 10.5056/jnm19014

Figure 9.

Figure 9

Transient receptor potential ankyrin 1 (TRPA1)-mediated extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation in nodose neurons after antral cold stimulation in naive rats. (A) Phospho-ERK1/2 (pERK 1/2) labeling in nodose neurons 10 minutes after intra-antral infusion of warm or cold (0°C) saline. Arrows indicate p-ERK1/2-immunoreactive (IR) neurons. **P < 0.01 (Student’s t test). (B) A-967079 (6 μg/mL; intra-antrally administered) suppressed ERK1/2 activation in nodose neurons induced by antral cold stimulation. (C) Double labeling for TRPA1 or transient receptor potential melastatin 8 (TRPM8) and p-ERK1/2 in nodose neurons after infusion of cold saline. Arrows indicate immunoreactive or double-labeled neurons. Scale bar = 100 μm. NG, nodose ganglia.