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. 2019 Jun 20;44(3):995–1005. doi: 10.3892/ijmm.2019.4250

Figure 4.

Figure 4

Regulation of SIRT1 on NF-κB and KLF4 following ABCD1 or HSD17B4 silencing. (A) Representative western blot images as well as (B) intensity quantification of p-IκBα, nuclear NF-κB and nuclear KLF4 in ABCD1 or HSD17B4 silenced HBMECs with or without sirtinol (20 µM) treatment at basal condition. (C) Representative western blot images as well as (D) intensity quantification of p-IκBα, nuclear NF-κB and nuclear KLF4 in ABCD1 or HSD17B4 silenced HBMECs with or without resveratrol (20 µM) treatment at basal condition. *P<0.05 and **P<0.01 vs. NT control group. #P<0.05. NT, non-targeting; ABCD, ATP binding cassette subfamily D member 1; HBMECs, human brain microvascular endothelial cells; TNF, tumor necrosis factor; NF, nuclear factor; si, small interfering; KLF4, Krüppel-like factor 4; NF, nuclear factor; p-IκBα, phosphorylated-inhibitor of NF-κB; NT, non-targeting.