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. 2019 Jul 8;44(3):913–926. doi: 10.3892/ijmm.2019.4269

Figure 5.

Figure 5

Effect of LS on the expression of NF-κB and MAPK signaling pathways. (A) Protein expression of NF-κB and p-NF-κB were measured by western blot analysis. (B) NF-κB and p-NF-κB expression was normalized to lamin B. (C) Protein expression of MAPKs were measured by western blot. (D) The expression of p-ERK1/2, p-JNK and p-p38 were normalized to total ERK1/2, JNK and p38, respectively. The results are presented as the means ± standard error of the mean (n=3). #P<0.05 and ##P<0.01 vs. normal; *P<0.05 and **P<0.01 vs. RANKL-induced control. LS, Leonurus sibiricus L.; NF-κB, nuclear factor-κB; MAPKs, mitogen-activated protein kinases; p-, phosphorylated; ERK1/2, extracellular signal-regulated kinase 1/2; JNK, c-Jun N-terminal kinase; RANKL, receptor activator of nuclear factor κ-B ligand.