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. 2019 Jul 8;44(3):913–926. doi: 10.3892/ijmm.2019.4269

Figure 6.

Figure 6

Effect of LS on the expression of essential transcription factors involved in osteoclastogenesis. (A) Expression of NFATc1 was measured by western blot and RT-PCR. (B) Protein and mRNA expression of NFATc1 was normalized to actin and GAPDH, respectively. (C) Expression of c-Fos was detected by western blot analysis and reverse transcription semi-quantitative PCR. (D) Protein and mRNA levels of c-Fos was normalized to actin and GAPDH, respectively. The results are presented as the means ± standard error of the mean (n=3). ##P<0.01 vs. normal; *P<0.05 and **P<0.01 vs. RANKL-induced control. LS, Leonurus sibiricus L.; NFATc1, nuclear factor of activated T-cells 1; RANKL, receptor activator of nuclear factor κ-B ligand.