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. 2019 Jun 24;44(3):835–846. doi: 10.3892/ijmm.2019.4253

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The mRNA level of chemokine receptors in the lower cervical spinal cord (C5-8) in the 3 groups. Fold changes of Ccr4, Ccr7, Cxcr2, Cxcr4 and Cxcr6 mRNA levels were significantly increased in both models of chronic itch compared with the naïve group. Gene expression levels of Ccr3 in the AEW group, and those of Ccr1, Ccr6, Ccr9 and Cxcr1 in the DCP group were significantly increased. Each value represents the mean ± SEM of 3 independent experiments (n=6-8 mice per group). ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. naïve mice. AEW, acetone/ether/water; DCP, diphenylcyclopropenone.