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. 2019 Jul 2;44(3):1078–1090. doi: 10.3892/ijmm.2019.4262

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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VEGF regulated occludin and ZO1 expression via the VEGFR2/PLCγ1/eNOS signalling pathway in bEnd.3 endothelial cells. (A) Representative images from western blot analysis for the proteins occludin (63 kDa), ZO1 (220 kDa) and β-actin (43 kDa), following different treatments, including OGD, 40 mM HS, SU5416 (VEGFR2 inhibitor), U73122 (PLCγ1 inhibitor) and L-NAME (eNOS inhibitor). (B) Quantification of western blotting results in each experimental group. ^*P<0.05 vs. control; and ^#P<0.05 vs. OGD. VEGF, vascular endothelial growth factor; ZO1, zonula occludens 1; VEGFR2, vascular endothelial growth factor receptor 2; PLCγ1, phospholipase C γ1; eNOS, endothelial nitric oxide synthase; OGD, oxygen-glucose deprivation; HS, hypertonic saline; Con, control.