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. 2019 Jul 15;15(7):e1007944. doi: 10.1371/journal.ppat.1007944

Fig 4. AM22, RSD5-GL, and D25 have overlapping epitopes at the apex of the RSV F trimer.

Fig 4

(A) Surface representations of a single AM22, RSD5-GL, and D25 Fab bound to the apex of the RSV F trimer, viewed looking along or toward the viral membrane. The three RSV F protomers are colored light green, tan, and pink. AM22 is colored purple, RSD5-GL is colored red, and D25 is colored blue. (B) Surface representations of the apex of the RSV F trimer highlight the epitope of each antibody on a single F protomer. The epitope for each antibody is shown on the green protomer, and the epitope itself is colored purple for AM22, red for RSD5-GL, and blue for D25. (C) The amino acid sequence of residues near RSV F site Ø is shown for both strain A2 and strain B9320. Diamond symbols above each residue indicate a contact between D25 and prefusion RSV F strain A2 based upon PDBePISA analysis of the crystal structure.