TABLE 3.
Test Characteristics of uNGAL and Screening Urine Tests
| Urine Test | Possible and Definite UTIs Combined (N = 260, 35 UTIs) | Definite UTIs (Possible Considered Negative) (N = 260, 22 UTIs) | ||
|---|---|---|---|---|
| Sensitivity % (95% CI) | Specificity % (95% CI) | Sensitivity % (95% CI) | Specificity % (95% CI) | |
| uNGAL ≥39.1 ng/mL | 97.1 (83.4–99.9) | 95.6 (91.7–97.7) | 100.0 (81.5–100.0) | 90.8 (86.2–94.0) |
| UA | ||||
| Nitrite (+) | 20.0 (9.1–37.5) | 100.0 (97.9–100.0) | 31.8 (14.7–54.9) | 100.0 (98.0–100.0) |
| ≥ Trace LE | 74.3 (56.4–86.9) | 97.3 (94.0–98.9) | 86.4 (64.0–96.4) | 94.5 (90.6–96.9) |
| LE ≥1+a | 60.6 (42.2–76.6) | 99.1 (96.4–99.8) | 80.0 (55.7–93.4) | 97.4 (94.2–98.9) |
| LE ≥2+a | 60.6 (42.2–76.6) | 100.0 (97.8–100.0) | 80.0 (55.7–93.4) | 98.3 (95.3–99.4) |
| LE ≥3+a | 60.6 (42.2–76.6) | 100.0 (97.8–100.0) | 80.0 (55.7–93.4) | 98.3 (95.3–99.4) |
| Nitrite (+) and ≥ trace LE | 20.0 (9.1–37.5) | 100.0 (97.9–100.0) | 31.8 (14.7–54.9) | 100.0 (98.0–100.0) |
| Either nitrite (+) or ≥ trace LE | 74.3 (56.4–86.9) | 97.3 (94.0–98.9) | 86.4 (64.0–96.4) | 94.5 (90.6–96.9) |
| Gram-stain | 74.3 (56.4–86.9) | 100.0 (97.9–100.0) | 95.5 (75.1–99.8) | 97.9 (94.9–99.2) |
a
Nine patients who only had POC dipstick testing completed were excluded from these analyses because POC LE tests were reported solely as having positive or negative results (rather than having trace results, 1+, 2+, or 3+).