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. Author manuscript; available in PMC: 2019 Jul 25.
Published in final edited form as: Nat Rev Clin Oncol. 2018 Jun;15(6):353–365. doi: 10.1038/s41571-018-0002-6

Fig. 2. Clinical trial designs invoking cancer genomics assays.

Fig. 2

Two basic clinical trial designs for the testing of genomically targeted cancer therapies have emerged. a | Basket trials place all patients with tumours expressing the same genomic target into the same ‘basket, enabling patients to receive a matched targeted therapy. b | Umbrella trials involve the investigation of multiple targeted therapies and the enrolment of specific groups of patients into different trials according to their tumour genotype. In both types of trials, a next-generation sequencing assay that enables the detection of many targetable alterations can provide information enabling patients to be included into one of multiple trial cohorts available within a cancer centre. Figure adapted from REF143, NRC Research Press, CC-BY-4.0 (https://creativecommons.org/licenses/by/4.0/).