Table 1. Summary of GTEx gene expression information used to build the gene-expression networks with descriptive statistics and P value thresholds for gene-based analyses.
| Tissue | Gene Network | Modules | Gene Module Size | eMAGMA | S-PrediXcan | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Samples | Genes | N | Min | Median | Max | Genes | Threshold | Genes | Threshold | |
| Amygdala | 88 | 16547 | 24 | 30 | 362 | 4125 | 1214 | 4.12E-05 | 2338 | 2.14E-05 |
| Anterior cingulate cortex | 109 | 16568 | 16 | 55 | 391 | 9144 | 2356 | 2.12E-05 | 3269 | 1.53E-05 |
| Caudate basal ganglia | 144 | 16612 | 16 | 75 | 483 | 6971 | 3272 | 1.53E-05 | 4142 | 1.21E-05 |
| Cerebellar Hemisphere | 125 | 16505 | 13 | 163 | 741 | 8662 | 4075 | 1.23E-05 | 4726 | 1.06E-05 |
| Cerebellum | 154 | 16607 | 15 | 86 | 613 | 8133 | 5386 | 9.28E-06 | 6044 | 8.27E-06 |
| Cortex | 136 | 16665 | 11 | 126 | 582 | 6188 | 3625 | 1.38E-05 | 4299 | 1.16E-05 |
| Frontal Cortex | 118 | 16642 | 22 | 51 | 345 | 4965 | 2952 | 1.69E-05 | 3565 | 1.40E-05 |
| Hippocampus | 111 | 16634 | 17 | 84 | 388 | 4168 | 1830 | 2.73E-05 | 2788 | 1.79E-05 |
| Hypothalamus | 108 | 16892 | 17 | 60 | 613 | 5322 | 1605 | 3.12E-05 | 2819 | 1.77E-05 |
| Nucleus accumbens | 130 | 16652 | 20 | 68 | 471 | 5346 | 2842 | 1.76E-05 | 3593 | 1.39E-05 |
| Putamen | 111 | 16399 | 15 | 53 | 695 | 7371 | 2401 | 2.08E-05 | 3153 | 1.59E-05 |
| Spinal cord cervical c-1 | 83 | 16809 | 20 | 56 | 577 | 3017 | 1470 | 3.40E-05 | 2501 | 2.00E-05 |
| Substantia nigra | 80 | 16612 | 19 | 73 | 475 | 5266 | 989 | 5.06E-05 | 2015 | 2.48E-05 |
| Whole Blood | 369 | 14834 | 14 | 57 | 293 | 6939 | 5946 | 8.41E-06 | 6249 | 8.00E-06 |
Proximity MAGMA used a P value threshold of P<2.77 × 10–6.