Table 2. Significant major depression candidate risk genes for three gene-based methods (MAGMA, eMAGMA, S-PrediXcan).
| MAGMA | eMAGMA | S-PrediXcan | |||||
|---|---|---|---|---|---|---|---|
| NAME | P | NAME | TISSUE | P | GENE | TISSUE | P |
| CACNA1E | 2.18E-14 | VARS2 | Whole Blood | 3.40E-13 | NEGR1 | Whole Blood | 2.05E-17 |
| OLFM4 | 6.21E-14 | NEGR1 | Whole Blood | 7.75E-13 | RPL31P12 | Brain Cerebellar Hemisphere | 4.01E-15 |
| NEGR1 | 3.57E-13 | PRSS16 | Brain Cerebellum | 2.78E-12 | RPL31P12 | Brain Cerebellum | 4.30E-15 |
| TMEM161B | 1.28E-12 | HLA-G | Whole Blood | 5.20E-12 | NEGR1 | Brain Putamen basal ganglia | 1.67E-12 |
| SORCS3 | 5.14E-12 | MICB | Brain Cerebellar Hemisphere | 5.37E-12 | CTC-467M3.3 | Brain Frontal Cortex BA9 | 3.45E-10 |
| HIST1H2BN | 1.25E-11 | FLOT1 | Whole Blood | 5.83E-12 | RP5-874C20.3 | Whole Blood | 5.06E-09 |
| DENND1A | 1.39E-11 | CCHCR1 | Whole Blood | 9.42E-12 | CTC-467M3.3 | Brain Cerebellar Hemisphere | 5.31E-09 |
| BTN2A1 | 1.47E-11 | MICB | Brain Cerebellum | 1.18E-11 | PGBD1 | Brain Cerebellum | 6.76E-09 |
| PRRC2A | 1.51E-11 | FLOT1 | Brain Cerebellum | 1.30E-11 | TMEM106B | Whole Blood | 1.21E-08 |
| TCF4 | 2.39E-11 | BTN3A2 | Whole Blood | 1.53E-11 | PGBD1 | Brain Cerebellar Hemisphere | 1.29E-08 |
| DCC | 3.27E-11 | C4B | Whole Blood | 1.12E-10 | ZSCAN23 | Brain Spinal cord cervical c-1 | 1.48E-08 |
| PXDNL | 3.84E-11 | NEGR1 | Brain Putamen basal ganglia | 1.15E-10 | ZSCAN31 | Brain Spinal cord cervical c-1 | 2.31E-08 |
| SHISA9 | 7.38E-11 | NEGR1 | Brain Spinal cord cervical c-1 | 1.16E-10 | OR2B8P | Brain Cerebellum | 3.78E-08 |
| BAG6 | 1.59E-10 | CCHCR1 | Brain Cerebellum | 1.23E-10 | SLC30A9 | Brain Hypothalamus | 4.80E-08 |
| RSRC1 | 1.74E-10 | C4A | Whole Blood | 2.03E-10 | ESR2 | Whole Blood | 6.75E-08 |