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. 2019 Jul 24;27(8):1292–1304. doi: 10.1002/oby.22521

Figure 4.

Figure 4

Indirect calorimetry and metabolic cage analysis of Abcc5‐/‐ mice. (A) Female oxygen consumption (VO2). (B) Female carbon dioxide release (VCO2). (C) Female energy expenditure (EE). (D) Male oxygen consumption (VO2). (E) Male carbon dioxide release (VCO2). (F) Male EE. All data were ANCOVA adjusted for lean mass. Total activity (XT) for (G) females and (H) males. Abcc5‐/‐ mice and wild‐type (wt) littermate controls (male:female:wt:Abcc5‐/‐ = 15:11:15:15) were individually housed for 24 hours in PhenoMaster cages at 12 weeks of age. Data in panels G and H shown as the average XT activity per hour plotted separately for light‐dark cycle for each mouse. Error bars: mean ± SEM; unpaired two‐tailed Student t test; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.