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. Author manuscript; available in PMC: 2020 May 10.

Published in final edited form as: Dev Neurosci. 2019 May 10;40(5-6):475–489. doi: 10.1159/000498968

Figure 6. — Greater fractional anisotropy (A) values were seen in the control group in the right internal capsule dorsolateral to the ventricle at the level of thalamus (marked in red). On T2-weighted imaging (B), significantly greater signal intensity was seen in the injured group throughout the white matter bilaterally (marked in blue). Network connectivity analysis showed three of 71 ROIs that were significantly different between injured and control animals (C). In ROI 3 (right internal capsule at the level of the mesencephalon), connectivity was greater in injured females, compared to control females. In the same ROI, connectivity in injured males was significantly decreased compared to control males. In ROI 19 (left internal capsule and associated white matter at the level of the caudate nucleus), mean connectivity was greater in injured males compared to control males. In ROI 20 (left internal capsule and associated white matter at the level of the caudate nucleus, ventral to ROI 19), mean connectivity was greater in injured females compared to control females. Overall connectivity projections (D) show control (left panels) and injured (right panels) animals, with points of increased connectivity in controls compared to injured animals (bottom left panel), and increased connectivity in injured compared to control animals (bottom right panel). Cerebral volumes (E) in injured females were significantly decreased compared to control females, but no difference in cerebral volume was seen between injured and control males. * denotes P<0.05.

Figure 6. — Greater fractional anisotropy (A) values were seen in the control group in the right internal capsule dorsolateral to the ventricle at the level of thalamus (marked in red). On T2-weighted imaging (B), significantly greater signal intensity was seen in the injured group throughout the white matter bilaterally (marked in blue). Network connectivity analysis showed three of 71 ROIs that were significantly different between injured and control animals (C). In ROI 3 (right internal capsule at the level of the mesencephalon), connectivity was greater in injured females, compared to control females. In the same ROI, connectivity in injured males was significantly decreased compared to control males. In ROI 19 (left internal capsule and associated white matter at the level of the caudate nucleus), mean connectivity was greater in injured males compared to control males. In ROI 20 (left internal capsule and associated white matter at the level of the caudate nucleus, ventral to ROI 19), mean connectivity was greater in injured females compared to control females. Overall connectivity projections (D) show control (left panels) and injured (right panels) animals, with points of increased connectivity in controls compared to injured animals (bottom left panel), and increased connectivity in injured compared to control animals (bottom right panel). Cerebral volumes (E) in injured females were significantly decreased compared to control females, but no difference in cerebral volume was seen between injured and control males. * denotes P<0.05.