Figure 2.
IMP-1002 Inhibition of Parental and Resistant Parasite Lines
(A) Inhibition of P. falciparum 3D7 and Dd2 parental parasites used to raise the resistant clones 01, 02, 03, and the uncloned population, showing the respective EC50 and confidence interval values rounded to two significant figures.
(B) Measurement of the inhibition of growth of the Dd2 parental line, the resistant uncloned population and three IMP-1002-resistant clones to determine the EC50 after 72 h (n = 3). There is a clear shift of the EC50 for the resistant bulk population and the three parasite clones. Error bars indicate standard deviation of the mean.