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. 2019 Jul 18;26(7):991–1000.e7. doi: 10.1016/j.chembiol.2019.03.015

Figure 4.

Figure 4

Consequences of G386E Substitution for NMT Function

Bar graphs showing the effect of the G386E substitution on (A) IC50 in the biochemical assay, (B) EC50 in the parasite growth assay, and (C) thermal shift in a protein stability assay with IMP-1002 (n = 2–3). For comparison, the effect of the substitution on these values is shown for another NMT inhibitor, DDD85646, which is not affected. All errors bars in this figure indicate standard deviation of the mean. For Figure 4C refer to the Tables S4A and S4B.