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. 2019 Jul 25;9:68. doi: 10.1186/s13550-019-0538-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Physiological biodistribution of ¹⁵²Tb-PSMA-617 on PET/CT scans (MIP images) obtained at a 50 min, b 2 h, c 18.5 h, and d 25 h, respectively, after injection of 140 MBq ¹⁵²Tb-PSMA-617. Physiological accumulation of the radioligand is observed in the blood pool (decreasing over time), lacrimal, parotid, and submandibular glands (strong), the nasopharyngeal mucosa as well as in the liver, spleen (faint), and the intestinal tract (increasing over time). Uptake in the kidneys and retention of activity in the urinary bladder are due to renal excretion of ¹⁵²Tb-PSMA-617. Mild background activity of the radioligand was observed in normal tissue which decreased over time