Table 3.
Organ injury and inflammation
| Parameter | Standard PLT dose | High PLT dose | ||
|---|---|---|---|---|
| Before injury | After 6 h | Before injury | After 6 h | |
| Respiratory | ||||
| PF-ratio (mmHg) | 507 (487–561) | 552 (372–621) | 521 (478–553) | 602 (517–620) |
| Coagulation | ||||
| Platelets (109/L)* | 877 (876–907) | 419 (125–629) | 1008 (946–1064) | 675 (185–739)# |
| Fibrinogen (g/L) | 1.5 (0.9–1.7) | 1.3 (0.3–1.4) | 1.6 (1.5–1.7) | 1.7 (1.7–1.9)* |
| LDH (U/L) | 129 (65–272) | 519 (156–1179) | 117 (80–211) | 452 (261–1653)# |
| Liver | ||||
| AST (U/L) | 63 (60–68) | 277 (152–385) | 66 (64–75) | 332 (216–390)# |
| ALT (U/L) | 55 (50–59) | 168 (107–2613)# | 57 (50–61) | 146 (110–546)# |
| Kidney | ||||
| Creatinine (μmol/L) | 25 (21–28) | 103 (49–162)# | 24 (22–26) | 73 (42–136)# |
| Urine protein (g/L) | 0.27 (0.08–0.55) | 4.44 (2.40–11.09) | 0.17 (0.10–0.33) | 2.08 (1.68–3.24)# |
| Inflammation | ||||
| Leukocytes (109/L)* | 7.1 (4.4–7.7) | 5.4 (5.2–6.6) | 7.1 (4.4–7.7) | 6.3 (4.9–7.7) |
| IL-6 (pg/mL) | < 4.1 | < 4.1 | < 4.1 | < 4.1 |
| IL-8 (pg/mL) | < 31.25 | < 31.25 | < 31.25 | < 31.25 |
| HMGB-1 (pg/mL) | 402 (390–481) | 689 (416–1877)# | 380 (353–424) | 659 (589–1276)# |
Data are presented as median (IQR)
PLT platelet transfusion, PF PaO2/FiO2, PT prothrombin time, AST aspartate aminotransferase, ALT alanine transaminase, LDH lactate dehydrogenase, IL-6 interleukin-6, IL-8 interleukin-8, and HMGB-1 high mobility group box 1
*p < 0.050 for differences between groups. #p < 0.050 for differences before and after 6 h within group