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. 2019 Jul 25;9:10808. doi: 10.1038/s41598-019-47149-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Control of numbers of HBcAg-expressing hepatocytes after therapeutic vaccination ± CpG injection in AAV-HBV-infected mice. (a) Time course of serum HBeAg and HBsAg levels after therapeutic heterologous prime-boost vaccination. (b,c) Liver immunohistochemistry of HBcAg-expressing hepatocytes at d32 and d63 after start of vaccination (d3 and d34 after CpG-injection) and quantification. (d) Flow cytometric evaluation of intracellular GzmB and IFNγ in HBcAg-specific CD8 T cells after restimulation ex vivo. Bars in (a,c,d) indicate mean value of n ≥ 3 mice per group + SEM. Statistical analyses was performed using (a) 2-way ANOVA with Tukey’s multiple comparison correction and (c,d) Kruskal-Wallis test with Dunn’s multiple comparison correction. Asterisks mark statistically significant differences: *p < 0.05; **p < 0.01; ns – not significant; n.d. – not detectable.