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Circular dichroism (CD) of KPC-2 (10 μM) (A) and the K234R variant (10 μM) (B) with nacubactam (Nacu; 100 μM) and avibactam (Avi; 100 μM). DBO binding to KPC-2 does not induce significant secondary structure changes (A). The binding of avibactam seems to partially restore the stability of the K234R variant, resulting in large secondary structure changes. Nacubactam induces only minor secondary structure changes in the K234R variant (B). θ, ellipticity.
