FIG 1.

MIC (μg/ml) frequency by genotype for 269 M. abscessus isolates (including those with intermediate phenotypes). Dotted lines represent the Clinical and Laboratory Standards Institute breakpoints for clarithromycin (≤2 μg/ml, sensitive; >2 to <8 μg/ml, intermediate; and ≥8 μg/ml, resistant). Induc, inducible resistance (the isolate is subspecies bolletii/abscessus with no other relevant mutation and thus genotypically predicted to show inducible resistance); truncated erm, massiliense isolate with truncated erm(41) gene and no other relevant mutations. All other mutations except T28C, which is a mutation in erm(41), represent nucleotide mutations in the rrl gene.