Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of wild-type HIV-1 protease (PRWT) enzymatic activity by GRL-057-14, GRL-058-14, GRL-059-14, APV, and DRV. All the compounds tested completely blocked PRWT activity at 100 nM and beyond. GRL-057-14 inhibited PRWT activity with an IC50 of 0.22 nM and a Morrison Ki of 0.10 nM.
