TABLE 1.
Means, medians, and standard deviations of population model parameter estimates for comodeling both strains 20KPN and 86KPNa
| Parameter | V | CL | Kg | Kkill | C50 | H | POPMAX | IC2 |
|---|---|---|---|---|---|---|---|---|
| Units | Liters | Liters/h | h−1 | h−1 | mg/liter | CFU/ml | CFU/ml | |
| Mean | 28.6 | 9.55 | 5.04 | 6.29 | 2.17 | 13.7 | 6.16 × 1010 | 2.58 × 108 |
| Median | 28.6 | 10.3 | 5.30 | 5.59 | 0.196 | 14.5 | 6.02 × 1010 | 1.44 × 108 |
| SD (%CV) | 3.52 (12.3) | 1.72 (18.0) | 0.609 (12.1) | 1.39 (22.1) | 3.02 (139) | 6.75 (49.1) | 4.00 × 109 (6.49) | 2.19 × 108 (85.1) |
a
V, volume of distribution; CL, clearance; Kg, first-order growth rate constant; Kkill, first order bacterial kill rate constant; C50, avibactam concentration at which the Kkill is half maximal; H, Hill’s constant (unitless); POPMAX, maximal total bacterial burden; IC2, initial bacterial burden.