FIG 3.
Predicted early bactericidal activity of GSK3036656 in tuberculosis patients. Analysis predicted the early bactericidal activity (EBA0–14) following 14 days of treatment with 5 to 25 mg once daily, based on the estimated PK/PD relationship in mouse infection models. Box plots represent the 5th, 25th, 50th, 75th, and 95th percentiles of the simulated individual EBA0–14. Numbers in parentheses represent the reported average EBA0–14 of each reference drug at therapeutic doses. PMD, pretomanid; BDQ, bedaquiline; OPC, delamanid.