TABLE 3.
Plasma pharmacokinetic parameters of GSK3036656 after single-dose administrationa
| Treatment dose (mg) for part A | Geometric mean AUC0–∞ (h · ng/ml) (%CVb) | Geometric mean AUC0–t (h · ng/ml) (%CVb) | Geometric mean Cmax (ng/ml) (%CVb) | Mean t1/2 (h) (SD) | Mean Tmax (h) (SD) |
|---|---|---|---|---|---|
| 5 (n = 6) | 1,404.5 (29.9) | 771.0 (26.0) | 49.06 (30.5) | 40.9 (16.1) | 1.1 (0.5) |
| 15 (n = 6) | 3,796.1 (19.8) | 3,252.9 (24.1) | 177.61 (23.1) | 28.4 (3.0) | 1.1 (0.6) |
| 25 (n = 6) | 6,557.8 (13.8) | 5,686.4 (11.4) | 207.38 (18.5) | 49.9 (13.1) | 1.1 (0.5) |
| 5 (fed) (n = 5) | 1,450.7 (9.4) | 782.8 (18.1) | 47.37 (23.5) | 34.8 (6.6) | 2.2 (1.3) |
a
%CVb, percent coefficient of variance between subjects.