TABLE 5.

Effect of food on plasma pharmacokinetic parameters of GSK3036656^a

Parameter	Treatment (mg)	Comparison	Test		Ref		Ratio	90% CI
			No. of subjects	Geometric LS mean	No. of subjects	Geometric LS mean
AUC0–∞ (h · ng/ml)	5	Fed vs fasted	5	1,348.60	6	1,428.33	0.94	0.71, 1.26
AUC0–t (h · ng/ml)	5	Fed vs fasted	5	786.54	6	731.74	1.07	0.87, 1.34
Cmax (ng/ml)	5	Fed vs fasted	5	46.98	6	48.42	0.97	0.76, 1.23
t1/2 (h)	5	Fed vs fasted	5	34.35	6	38.64	0.89	0.64, 1.23
Tmax (h)	5	Fed vs fasted	5	2.00	6	1.25	0.75b	−0.50, 2.50

^aCI, confidence interval; LS, least squares; Ref, reference.

^bDifference.