TABLE 6.
Plasma GSK3036656 pharmacokinetic parameters assessing accumulationa
| Parameter | Treatment regimen | Comparison | Test |
Ref |
Ratio | 90% CI | ||
|---|---|---|---|---|---|---|---|---|
| No. of subjects | Geometric LS mean | No. of subjects | Geometric LS mean | |||||
| AUC(Ro) (h · ng/ml) | Repeat 5 mg | Day 14 vs day 1 | 7 | 1,392.22 | 7 | 485.56 | 2.87 | 2.56, 3.21 |
| Repeat 15 mg | Day 14 vs day 1 | 8 | 4,461.26 | 8 | 1,891.04 | 2.36 | 2.12, 2.62 | |
| RoCmax (ng/ml) | Repeat 5 mg | Day 14 vs day 1 | 7 | 97.04 | 7 | 48.40 | 2.01 | 1.69, 2.37 |
| Repeat 15 mg | Day 14 vs day 1 | 8 | 309.55 | 8 | 178.79 | 1.73 | 1.48, 2.03 | |
a
CI, confidence interval; LS, least squares; Ref, reference.