TABLE 1.

Ranges of antifungal susceptibilities, geometric means, and MIC₅₀s of the species studied

Group (no. of isolates)	MIC (mg/liter)a
	AMB	NAT	TRB	ISA	ITC	POS
C. recurvatus (3)
GMb	0.03	2.0	40.3	5.0	3.2	3.2
MIC50	NAc	NA	NA	NA	NA	NA
Range	≤0.03	2	16–32	2–8	0.125–8	0.125–8
M. amphibiorum (3)
GM	0.03	1.6	20.2	16.0	0.1	0.04
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03	1–2	8–32	>8	0.06–0.5	0.016–0.125
M. ardhlaengiktus (2)
GM	0.04	2.8	64	16.0	16.0	16.0
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–0.06	2–4	>32	>8	>8	>8
M. circinelloides (14)
GM	0.1	1.9	64	5.1	3.1	0.6
MIC50	0.125	2	>32	4	4	0.5
Range	≤0.03–0.5	1–4	>32	2–8	0.5–8	0.125–4
M. griseocyanus (4)
GM	0.1	2.0	64	6.7	2.8	0.6
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–0.5	2	>32	4–8	2–4	0.25–1
M. indicus (10)
GM	0.04	2.5	64	16.0	13.0	2.8
MIC50	0.03	2	>32	>8	8	1
Range	≤0.03–0.125	2–4	>32	>8	2–8	0.25–8
M. irregularis (7)
GM	0.03	1.8	64	10.8	4.0	0.3
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03	1–2	>32	4–8	0.5–8	0.125–2
M. janssenii (5)
GM	0.08	1.5	64	3.0	1.5	0.3
MIC50	NA	NA	NA	4	2	0.125
Range	≤0.03–0.5	1–4	>32	2–4	0.5–4	0.06–0.5
M. lusitanicus (13)
GM	0.08	2.5	64	13.6	12.3	9.4
MIC50	0.06	2	>32	>8	8	8
Range	≤0.03–0.25	1–4	>32	4–8	2–8	1–8
M. racemosus (4)
GM	0.06	2.0	2.8	0.3	0.6	0.1
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–0.5	1–4	0.06–32	≤0.016–2	0.016–2	0.016–0.5
M. ramosissimus (1)
GM
MIC50
Range	0.06	1	>32	>8	>8	>8
M. variicolumellatus (2)
GM	0.03	1.4	64	5.7	0.7	0.7
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03	1–2	>32	4–8	0.5–1	0.5–1
M. velutinosus (7)
GM	0.04	2.2	64	2.4	1.1	0.3
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–0.125	2–4	>32	2–4	0.5–4	0.125–2
Mucoraceae
GM	0.06	2.02	51.09	6.59	3.57	0.98
MIC50	0.03	2	>32	8	2	0.5
Range	≤0.03–0.5	1–2	0.06–32	≤0.016–8	0.016–8	0.016–8
R. arrhizus (6)
GM	0.2	4.5	57.0	1.1	1.8	0.3
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–2	2–8	32–32	0.5–4	0.5–8	0.125–1
R. microsporus (6)
GM	0.6	2.6	0.1	1.7	2.2	0.5
MIC50	NA	NA	NA	NA	NA	NA
Range	0.25–1	2–4	≤0.06–0.5	1–4	1–8	0.125–2
Rhizopus spp.
GM	0,41	3.5	2.64	1.37	2	0.37
MIC50	0.5	4	0.5	1	1	0.5
Range	≤0.03–2	2–8	≤0.06–32	0.5–4	0.5–8	0.125–2
L. ramosa (2)
GM	0.03	2.0	0.18	2.8	0.7	0.06
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03	2	0.125–0.25	2–4	0.25–2	0.03–0.125
L. corymbifera (8)
GM	0.11	2.8	0.09	1.8	0.5	0.1
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–0.5	2–4	≤0.06–0.25	0.5–4	0.25–2	0.06–0.5
Lichtheimia spp.
GM	0.09	2.64	0.10	2	0.57	0,12
MIC50	0.125	2	0.06	2	0.5	0.125
Range	≤0.03–0.5	2–4	≤0.06–0.25	0.5–4	0.25–2	0.03–0.5
R. pusillus (4)
GM	0.07	2.5	0.1	2.8	0.2	0.1
MIC50	NA	NA	NA	NA	NA	NA
Range	≤0.03–0.25	2–4	≤0.06–1	0.25–8	0.125–8	0.03–1
Lichtheimiaceae
GM	0.07	2,56	0.11	2.1	0,53	0,11
MIC50	0.06	2	0.06	2	0.5	0.125
Range	≤0.03–0.5	2–4	≤0.06–1	0.25–8	0.125–8	0.03–1

^aAMB, amphotericin B; NAT, natamycin; TRB, terbinafine; ISA, isavuconazole; ITC, itraconazole; POS, posaconazole.

^bGM, geometric mean.

^cNA, not applicable.