FIG 3.

Effect of favipiravir in the specific activity of RVFV. (A) Viral titers of RVFV after each passage (n = 4) in the absence (white columns) or presence (black columns) of 40 μM favipiravir (redrawn from data shown in Fig. 2A). (B) Quantification by qRT-PCR (in triplicate) of RNA extracted from the supernatants of untreated (white columns) or 40 μM favipiravir-treated (black columns) Vero cells after each passage (n = 4). (C) Specific infectivity upon passage of RVFV in the absence (open symbols) or presence (closed symbols) of 40 μM favipiravir. Values correspond to the ratio between infectivity (A) and the amount of viral RNA (B). Error bars denote SD. Statistically significant differences are indicated by asterisks (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.005; ****, P ≤ 0.0001; Student's t test).